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Effects of Lepidium Sativum (Tuffa) on Bone Mineral Density and Symptoms in Female University Students in Makkah, Saudi Arabia: Single-Blind Randomized Trail
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Volume 5, 2018
Issue 3 (September)
Pages: 48-54   |   Vol. 5, No. 3, September 2018   |   Follow on         
Paper in PDF Downloads: 28   Since Jul. 26, 2018 Views: 407   Since Jul. 26, 2018
Hassan M. Bukhari, Clinical Nutrition Department, Faculty of Applied Medical Sciences, Umm al Qura University, Makkah, Saudi Arabia.
Hala M. Wahba, Home Economics Department, Faculty of Specific Education, Minufiya University, Minufiya, Egypt; Home Economics Department, Faculty of Sciences and Arts (Buljurshi) Al-Baha University, Buljurishi, KSA.
Eslam A. Header, Clinical Nutrition Department, Faculty of Applied Medical Sciences, Umm al Qura University, Makkah, Saudi Arabia; Department of Nutrition and Food Science Faculty of Home Economics Minufiya University, Minufiya, Egypt.
Anan A. Sharkar, Clinical Nutrition Department, Faculty of Applied Medical Sciences, Umm al Qura University, Makkah, Saudi Arabia.
Nadin A. Al-saegh, Clinical Nutrition Department, Faculty of Applied Medical Sciences, Umm al Qura University, Makkah, Saudi Arabia.
Saja M. Bukhari, Clinical Nutrition Department, Faculty of Applied Medical Sciences, Umm al Qura University, Makkah, Saudi Arabia.
Hyafa H. Aamoudi, Clinical Nutrition Department, Faculty of Applied Medical Sciences, Umm al Qura University, Makkah, Saudi Arabia.
Background: Osteoporosis affecting millions worldwide, with up to 200 million at risk of fracture. The seeds of Lepidium sativum (LS) are used in Saudi Arabia as traditional medicine (named Tuffa) to promote healing of fractured bone. Objectives: To study the effect of Tuffa on bone mineral density (BMD) and changes on symptoms after consumption. Subjects and methods: A Clinical trial was conducted between 2014 – 2015 in 72 randomly selected university females' students. They were given daily dose of LS (2.5g for 6 weeks). A questionnaire was used for personal and bone health. Symptoms related to joint pain and stiffness and body health before and after treatment were also measured. BMD measured by DEXA. Results: Osteopenia occurred but no osteoporotic cases were reported, with significant changes from baseline after treatment from 40% osteopenic cases to 30.6%. T-Score at baseline improved from ـ0.702±1.038 to -0.61±0.984 after treatment. Total BMD was 1.078±0.103 lowered to 1.067±0.092; Hip BMD was 0.904±0.134 lowered to 0.8732±0.133. Spinal (BMD) was 1.0092 ±0.134 increased to 1.0172±0.126, only the hip and T-score changes were significant (P<0.05). Stiffness and pain in the knee joints, hair loss, and dizziness improved after treatment (P<0.05) Conclusion: Tuffa (L.S.) improves bone structure and health related symptoms. A good herbal medicine may protect young adults, particularly those with family history and poor dietary and life style.
Osteoporosis, Osteopenia, Lepidium Sativum, Tuffa, BMD, Makkah, Saudi Arabia
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