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Wound Healing Potentials of Extarct of Gambia albidum Bark
Current Issue
Volume 2, 2015
Issue 5 (September)
Pages: 149-153   |   Vol. 2, No. 5, September 2015   |   Follow on         
Paper in PDF Downloads: 63   Since Sep. 3, 2015 Views: 1763   Since Sep. 3, 2015
Authors
[1]
Uraku A. J., Department of Biochemistry, Ebonyi State University, Abakaliki, Ebonyi State, Nigeria.
[2]
Afiukwa C. A., Department of Biotehnology, Ebonyi State University, Abakaliki, Ebonyi State, Nigeria.
[3]
Ezeali C., Department of Biochemistry, Ebonyi State University, Abakaliki, Ebonyi State, Nigeria.
[4]
AZI S. O., Department of Biotehnology, Ebonyi State University, Abakaliki, Ebonyi State, Nigeria.
[5]
Nwele D. E., Department of Medical Laboratory Sciences, Ebonyi State University, Abakaliki, Ebonyi State, Nigeria.
[6]
Uhuo A. C., Department of Medical Laboratory Sciences, Ebonyi State University, Abakaliki, Ebonyi State, Nigeria.
[7]
Ugwuokechukwu P. C., Department of Biochemistry, Ebonyi State University, Abakaliki, Ebonyi State, Nigeria.
Abstract
Wounding healing potentials of ethanol and ethylacetate bark extracts of Gambia albidum was determined. The extracts were used as a suppension in olive oil in a ratio of 2:1 for topical traetment of 2cm wounds. A total of eighteen albino rats were used for the study and the albino rats were divided into three groups namely; A, B and C of six animals each. Group A and B were given ethanol and ethylacetate suppension respectively while C was given olive oil. The result showed that the ethanol suppenssion was more effective than ethylacetate in reducing the diameters of 2cm wound on the albino rats. There was a general significant increase (P<0.05) in proteinase activities, total protein, ascorbic acid and cortisol levels in both extracts but there was a general significant decrease (P<0.05) in zinc and lipid peroxiodation levels of both extracts. The study concludes that the ethanol and ethylacetate extracts were effective in enhancing wound healing but ethanol extract was more effective.
Keywords
Nutrition and Diet, Wound, Medicinal Plants, Chemical Constituents
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