The global warming results in increase in endosymbiotic archaeal growth and neanderthalisation of the homo sapien species. The archaea can catabolize cholesterol generating digoxin which can induce redox stress. Global warming related osmotic stress and and digoxin induced redox stress leads to induction of the enzyme aldose reductase which converts glucose to sorbitol. Sorbitol is acted upon by sorbitol dehydrogenase and converted to fructose. Fructose can enter three metabolic schemes. The fructose is converted to alpha glycerophosphate and triglycerides. This results in storage of glucose and fructose as fat and a fat storage syndrome. The fructose can also enter the glucosamine pathway resulting in GAG synthesis and accumulation of mucopolysaccharides and proteoglycans. The fructose has got a low km value for ketokinases as compared to glucose and gets selectively phosphorylated. This results in cellular depletion of ATP. The fructosemia can lead to increased ribose synthesis via the pentose phosphate pathway inducing nucleic acid synthesis and cell proliferation. This can lead to oncogenesis. The fructosemia can lead to fructosylation of proteins producing antigenic proteins. This leads to autoimmune disease. Fructose can inhibit brain derived neurotrophic growth factor and lead to genesis of schizophrenia and autism. The cellular depletion of ATP due to fructose phosphorylation can lead to cell death and neurodegeneration. The inhibition of glucose phosphorylation due to ATP depletion produces inhibition of glucose metabolism resulting in hyperglycemia and metabolic syndrome.
Dr. Ravikumar Kurup trained in Internal Medicine, Neurology and Metabolic Medicine at Medical College, Trivandrum and Christian Medical College, Vellore. He holds a doctorate degree in Internal Medicine and Neurology. He is a member of the National Academy of Medical Sciences, India. He works as Professor of Metabolic Medicine and Metabolic Neurology at Metabolic Disorders Research Center, Trivandrum. He also works as Professor of Internal Medicine and Head of the divisions of Metabolic Medicine and Hematology at Medical College Hospital, Trivandrum. His areas of research interests are in Neurochemistry and Metabolic Medicine.
Parameswara Achutha Kurup
The Metabolic Disorders Research Centre, TC 4/1525, Gouri Sadan, Kattu Road North of Cliff House, Kowdiar PO Trivandrum, Kerala, India.
Experts in Neurology, Psychiatry, Metabolonomics, Internal Medicine, Biochemistry, Climatology