The human brain synthesizes an endogenous membrane sodium potassium ATPase inhibitor digoxin which plays a role in neuro-immuno-endocrine integration and pathogenesis of several neuropsychiatric and systemic diseases. Endogenous digoxin has been related to hemispheric dominance. Right hemispheric dominant individuals were hyperdigoxinemic, left hemispheric dominant individuals were hypodigoxinemic and bihemispheric dominant individuals were normodigoxinemic. The possibility of endogenous digoxin synthesis by actinide based primitive organism like archaea with a mevalonate pathway and cholesterol catabolism was considered. Davies has put forward the concept of a shadow biosphere of organisms with alternate biochemistry present in earth itself8. An actinide dependent shadow biosphere of archaea and viroids in the neuropsychiatric disease states is described. The intracellular endosymbionts archaea and their intron derived viroids constitute the third element regulating the human body.
| The Full Book PDF |
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| Front Matter |
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| Chapter 1 Actinide Dependent Shadow Biosphere of Archaea and Viroids and Hemispheric Dominance |
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| Chapter 2 Neanderthalic Actinide Dependent Shadow Biosphere of Archaea and Viroids and Hemispheric Dominance |
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| Chapter 3 The Right Hemispheric and Cerebellar Dominant Brain - Endosymbiotic Archaeal Metabolonomics, Neoneanderthalisation and Human Disease -The Origins of Cancer, Autoimmune Disease, Neurodegeneration, Metabolic Syndrome X and Schizophrenia/Autism - Relation to Retroviral Resistance |
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| Chapter 4 A Biological Basis for Philosophy, Economics, History, Politics, Literature, Social Movements, Feminism, Alternate Sexuality and Globalisation -The Right Hemispheric and Cerebellar Dominant Brain |
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| Back Matter |
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Ravikumar Kurup
Dr. Ravikumar Kurup trained in Internal Medicine, Neurology and Metabolic Medicine at Medical College, Trivandrum and Christian Medical College, Vellore. He holds a doctorate degree in Internal Medicine and Neurology. He is a member of the National Academy of Medical Sciences, India. He works as Professor of Metabolic Medicine and Metabolic Neurology at Metabolic Disorders Research Center, Trivandrum. He also works as Professor of Internal Medicine and Head of the divisions of Metabolic Medicine and Hematology at Medical College Hospital, Trivandrum. His areas of research interests are in Neurochemistry and Metabolic Medicine.
Parameswara Achutha Kurup
The Metabolic Disorders Research Centre, TC 4/1525, Gouri Sadan, Kattu Road North of Cliff House, Kowdiar PO Trivandrum, Kerala, India.
Experts in Neurology, Psychiatry, Philosophy, Cognitive Neurology, Neuropsychiatry, Psychology
