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Climate Change and Human Metabolonomic Evolution
Author:
Ravikumar Kurup,  Parameswara Achutha Kurup
ISBN: 978-1-941926-48-2
6.3 x 9.1 inches, 244pp, Paperback: $110
Published Date: June, 2016
To order hard copies, please contact book@openscienceonline.com
Introduction
Climate change and related stress leads to increased porphyrin synthesis leading on to the generation of porphyrions. Climatic changes of global warming and ice age can induce heme oxygenase which depletes heme inducing porphyrin synthesis. Defect in heme synthesis and heme depletion leads to deficiency of heme enzymes. Deficiency cytochrome C oxidase and aconitase leads to mitochondrial oxidative phosphorylation defects and TCA cycle defects. There is increase in glycolysis consequent to porphyrin photo-oxidation induced free radical generation and HIF alpha induction. This produces the Warburg phenotype. Deficiency of acetyl CoA leads to defects in the isoprenoid pathway and defective synthesis of cholesterol and ubiquinone. The porphyrins can have quantal perception of low level EMF fields leading to prefrontal cortex atrophy and cerebellar dominance. This leads onto Neanderthalisation of the brain and schizophrenia and autism. The mitochondrial dysfunction leads onto insulin resistance and metabolic syndrome x as well as neurodegeneration. The Warburg phenotype and increased glycolysis leads to oncogenesis. The increase in lymphocyte glycolysis can produce immune activation and autoimmune disease. Thus the stress induced porphyria due to climatic change and environmental pollution can lead to civilizational disease.
Contents
The Full Book PDF PDF
FrontMatter PDF
Chapter 1 Climate Change and Generation of Porphyrions PDF
Chapter 2 Global Warming Induced Archaeaon - A New Cell Organelle - The Master Organelle of the Cell PDF
Chapter 3 Global Warming Induced Porphyrions - Role of Porphyrins in Environmental Communication/Modulation of Digital Information Storage/Processing System - Low Level of Electromagnetic Fields and Human Disease - Porphyrions, the Internet and Mind PDF
Chapter 4 Global Warming Induced Extinction of Homo Sapiens and Symbiotic Neanderthalisation - Relation to Archaeal Mediated RNA Viroids and Amyloidosis PDF
Chapter 5 Global Warming Induced Endosymbiotic Actinidic Archaeal Synthesis of Bile Acids from Cholesterol Regulates Cellular Function PDF
Chapter 6 Global Warming Induced Endosymbiotic Actinidic Archaeal Synthesis of PAH from Cholesterol Regulates Cell Function PDF
Chapter 7 Global Warming Induced Endosymbiontic Actinidic Archaeal Synthesis of Digoxin from Cholesterol Regulates Cellular Function and Contributes to Disease Pathology PDF
Chapter 8 Global Warming Induced Endosymbiotic Actinidic Archaeal Generation of Ammonia and Thiocyanate Regulates Cell/Neuro-Immuno-Endocrine System and Provides a Substrate for Archaeal Energetics PDF
Chapter 9 Global Warming Induced Endosymbiotic Actinidic Archaeal Synthesis of Pyruvate from Cholesterol and the GABA Shunt Pathway Regulates Cell Function PDF
Chapter 10 Global Warming Induced Endosymbiotic Actinidic Archaeal Synthesis of Short Chain Fatty Acid Butyrate and Propionate from Cholesterol Regulates Cellular Function PDF
Chapter 11 Global Warming Induced Endosymbiotic Actinidic Archaeal Synthesis of Neurotransmitters by Cholesterol Catabolism Regulates Brain Function PDF
Chapter 12 Global Warming Induced Membrane Sodium Potassium ATPase Inhibition Mediated ATP Synthesis Induced by Digoxin, Photoinduction and Electromagnetic Fields PDF
Chapter 13 Global Warming Induced Endosymbiotic Actinidic Archaeal Digoxin Inhibited Sodium Potassium ATPase Mediated ATP Synthesis and Archaeal Ectoatpases Produce Neuro-Immuno-Metabolic-Endrocrine/Cell Cycle Regulation PDF
Chapter 14 Global Warming Induced Endosymbiotic Actinidic Archaeal Mediated Warburg Phenotype Mediates Human Disease State PDF
Chapter 15 Global Warming Induced Endosymbiotic Actinidic Archaeal Cholesterol Catabolic Syndrome - Hypocholesterolemia and Human Diseases PDF
Chapter 16 Global Warming Induced Endosymbiotic Actinidic Archaea and Viroids - Role in Metabolic/Endocrine Regulation PDF
Chapter 17 Global Warming Induced Stem Cell Conversion Produces an Epidemic Benjamin Buttons Reverse Aging Syndrome PDF
Chapter 18 Global Warming Induced Endosymbiotic Actinidic Archaea and Viroids - Role in Genomic Regulation PDF
Chapter 19 Global Warming Induced Neo-neanderthalisation and Metabolic Syndrome - Type 2 Diabetes Mellitus with Coronary Artery Disease and Stroke PDF
BackMatter PDF
Author(s)
Ravikumar Kurup
Dr. Ravikumar Kurup trained in Internal Medicine, Neurology and Metabolic Medicine at Medical College, Trivandrum and Christian Medical College, Vellore. He holds a doctorate degree in Internal Medicine and Neurology. He is a member of the National Academy of Medical Sciences, India. He works as Professor of Metabolic Medicine and Metabolic Neurology at Metabolic Disorders Research Center, Trivandrum. He also works as Professor of Internal Medicine and Head of the divisions of Metabolic Medicine and Hematology at Medical College Hospital, Trivandrum. His areas of research interests are in Neurochemistry and Metabolic Medicine.
Parameswara Achutha Kurup
The Metabolic Disorders Research Centre, TC 4/1525, Gouri Sadan, Kattu Road North of Cliff House, Kowdiar PO Trivandrum, Kerala, India.
Readership
Experts in Neurology, Psychiatry, Medicine, Evolutionary Biology, Neuro-philosophy, Psychology
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