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Synthesis and Biological Activity of Novel Hydrazide-Hydrazones Incorporating Piperidine and Piperazine Moieties and Related Mannich Bases
Current Issue
Volume 6, 2019
Issue 2 (April)
Pages: 58-65   |   Vol. 6, No. 2, April 2019   |   Follow on         
Paper in PDF Downloads: 98   Since May 19, 2019 Views: 1312   Since May 19, 2019
Authors
[1]
Elsayed Mohamed Afsah, Chemistry Department, Science Faculty, Mansoura University, Mansoura, Egypt.
[2]
Ebrahim Abdel-Galil, Chemistry Department, Science Faculty, Mansoura University, Mansoura, Egypt.
[3]
Ibrahim Youssef, Chemistry Department, Science Faculty, Mansoura University, Mansoura, Egypt.
[4]
Yasmin H Elsaedy, Chemistry Department, Science Faculty, Mansoura University, Mansoura, Egypt.
Abstract
Reaction of the hydrazide 2, or the bis(hydrazide) 8, with the appropriate aromatic aldehyde gave the new hydrazide-hydrazones 3a-g and 9a-g, respectively. Mannich reaction of 3e-g and 9e-g, with formalin and piperidine afforded the corresponding phenolic Mannich bases 4-6 and 10-12. The chemical structures of the prepared compounds were elucidated using spectral data. The biological activity including antioxidant and antimicrobial activity of the synthesized compounds were investigated. Compounds 3b, 3e, 3g and 9b showed the highest antioxidant activity, while the antimicrobial activity of compounds 3e, 3g and 9b showed the highest activity against E. coli. Moreover, compounds 3b, 3e, 3g, 9b and 9g have highest activity against S. aureus, and compounds 3b, 3e, 3g and 9g showed highest activity against C. Albicans.
Keywords
Hydrazide-Hydrazones, Bis (Hydrazide-Hydrazones), Phenolic Mannich Bases
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