Welcome to Open Science
Contact Us
Home Books Journals Submission Open Science Join Us News
Assessment of Seminal Trace Elements Levels in Infertile Nigerian Males
Current Issue
Volume 5, 2018
Issue 4 (August)
Pages: 42-48   |   Vol. 5, No. 4, August 2018   |   Follow on         
Paper in PDF Downloads: 33   Since Jul. 24, 2018 Views: 1039   Since Jul. 24, 2018
Uwanaka Oluchi Chioma, Department of Medical Laboratory Science, Ambrose Alli University, Ekpoma, Nigeria.
Iweka Kenneth Friday, Department of Medical Laboratory Science, Ambrose Alli University, Ekpoma, Nigeria.
Dic-Ijiewere Ebenezer Oseremen, Department of Chemical Pathology, Ambrose Alli University, Ekpoma, Nigeria.
Humans are exposed daily to environmental pollutants and environmental chemicals such as heavy metals are thought to adversely affect human reproductive function. A total of One hundred and twenty (120) subjects were used for the study of which seventy (70) of the subjects were infertile men classified as Oligospermic (n=15), Azospermic (n=16) and Asthenoligospermic (n=39) men according to their spermiogrames, while fifty (50) were used as control subjects (normospermic). The seminal levels of these trace elements were determined using the atomic absorption spectrophotometry. The mean seminal fluid concentration of lead (15.36 ± 5.91 µg/l) and Chromium (8.90 ± 4.39 µg/l) of infertile men were found to be statistically significant (p<0.05) when compared with the control subjects (17.63±5.43 µg/l; 7.35±2.38 µg/l respectively) while the mean seminal fluid concentration of selenium (2.01± 0.61µg/l), zinc (89.55±24.59 µg/l), cadmium (3.35± 1.52µg/l) of infertile men when compared with the control subjects (1.87±0.44 µg/l; 86.15±17.58 µg/l and 3.64±1.63 µg/l respectively) were not statistically significant (p>0.05). Hence, nutritional and biochemical factors may affect male reproduction.
Semen, Trace, Infertile, Lead, Chromium, Selenium, Zinc, Cadmium
Aitken, R. J. (2006): Sperm Function Test and Infertility. Int. J of Urol. 29: 69-75.
Templeton, A. A. (1992): The Epidemiology of Infertility. In Templeton, A. A. and Drife, J. O., Infertility. pringer-Verlag, Berlin, pp. 23-34.
World Health Organization (2000): Diagnosis and Management of the Infertile Male.91/P. Cambridge University Press.
Dereck, L. J. (1982): Infertility and Childlessness. Fundamentals of Obstetrics and Gynaecology. 3rdedition. Volume 2. Pp. 106-117.
Kuku, S. F. and Osegbe, D. N. (1989): Oligospermia and Azospermia in Nigerian Males. Arch. of Androl. 22 (3): 233-238.
Carlsen, E., Giwercman, A. and Keiding, N. (1992): Evidence for decreasing quality of semen during the past 50 years. Br. Med. J. 305: 609-613.
Auger, J., Kunstmann, J. M. and Czyglik, F. (1995): Decline in Semen Quality Among Fertile Men in Paris during the past 20 years. N. Engl J. Med., 332: 281-285.
Adamopoulos, D. A., Pappa, A. and Nicopoulou, S. (1996): Seminal Volume and Total Sperm Number Trends in Men Attending Subfertility Clinics in the Greater Athens Area. Hum. Reprod. 9: 1936-1941.
Berker, S. and Berhane, K. (1997): A Meta-Analysis of 61 Sperm Count Studies Revised. Fertil. Steril. 67: 1103-1108.
Swan, S. H., Elkin, E. P. and Fenster, L. (2000): The Question of Declining Sperm Density Revisited: An Analysis of 101 Studies. Environ. Health Persp. 108: 961-966.
Friberg, L. and Vahter, M. (1983): Assessment of Exposure to Lead and Chromium, Through Biological Monitoring: Results of a UNEP/WHO global study. Environ. Res. 30: 95-128.
Svensson, B. G., Bjornham, A. and Schutz, A. (1987): Acidic Deposition and Human Exposure to Toxic Metals. Sci. Total Environ. 67: 101-115.
Sram, R. J., Benes, I. and Binkova, B. (1996): Teplice Program- The Impact of Air Pollution on Human Health. Environ. Health Perspect. 104 (4): 699-714.
Benin, A. L., Sargent, J. D. and Dalton, M. (1999): High Concentrations of Heavy Metals in Neighbourhoods near Ore Smelters in Northern Mexico. Environ. HealthPerspect. 107: 279-284.
Banfalui, G. (2011): “Heavy metals, trace elements and their Cellular effects”. In Banfalui, G. Cellular Effects of Heavy Metals. Springer. Pp. 3-28. ISBN 9789400704275.
Baldwin, D. R. and Marshall, N. J. (1999): “Heavy metal poisoning and its Laboratory Investigations”. Annals of Clinical Biochemistry. 36 (3): 267-300.
World Health Organization (2004): Guidelines for drinking water quality, vol 1–2, Geneva, Switzerland.
Fufeyin, T. P. and Egborge A. B. M. (1998): Heavy metals of Ikpoba River, Benin, Nigeria. Tropical Freshwater Biology. 7: 27–36.
WHO/FAO/IAEA (1996): World Health Organization. Switzerland: Geneva; Trace Elements in Human Nutrition and Health.
Dic-Ijiewere, O. E., Okogun, G. R. A., Iweka, F. K., Airhomwanbor, K. O., Eidangbe, A. P., Idehen, I. C., Uwuigbe, M., Dic-Ijiewere, O. M. (2016): Assessment of Some Micronutrients Levels in Domestic Water Sources in Esan, Edo State. IJCR. 2016; 5 (4): 151-160.
Wang, S. and Shi, X. (2001): Molecular mechanisms of metal toxicity and carcinogenesis. Molecular and Cell Biochemistry. 222: 3–9.
Beyersmann, D. and Hartwig, A. (2008): Carcinogenic metal compounds: recent insight into molecular and cellular mechanisms. Archives of Toxicology 82 (8): 493–512.
Tchounwou, P. B., Centeno, J. A. and Patlolla, A. K. (2004): Arsenic toxicity, mutagenesis and carcinogenesis - a health risk assessment and management approach. Molecular and Cell Biochemistry. 255: 47–55.
Tchounwou, P. B., Ishaque, A., and Schneider, J. (2001): Cytotoxicity and transcriptional activation of stress genes in human liver carcinoma cells (HepG2) exposed to cadmium chloride. Molecular and Cell Biochemistry. 222: 21–28.
Patlolla, A., Barnes, C., Yedjou, C., Velma, V., and Tchounwou, P. B. (2009): Oxidative stress, DNA damage and antioxidant enzyme activity induced by hexavalent chromium in Sprague Dawley rats. Environmental Toxicolog. 24 (1): 66–73.
Yedjou, G. C. and Tchounwou, P. B. (2008): N-acetyl-cysteine affords protection against lead-induced cytotoxicity and oxidative stress in human liver carcinoma (HepG2) cells. International Journal of Environmental Research and Public Health. 4 (2): 132–137.
Sutton, D., Tchounwou, P. B., Ninashvili, N., and Shen, E. (2002): Mercury induces cytotoxicity, and transcriptionally activates stress genes in human liver carcinoma cells. International Journal of Molecular Science. 3 (9): 965–984.
Danielson, B. R. G., Dencker, L., and Lindgren, A. (1984): Accumulation of Toxic Metals in Male Reproductive Organs. Arch. Toxicol. Pp 177-180.
Stachel, B., Dougherty, R. C. and Lahl, U. (1989): Toxic Environmental Chemicals in Human Semen: Analytical Method and Case Studies. Androl. 21: 282-291.
Oguntibeju, O. O., Esterhuge, J. S. and Truter, E. J. (2009): Selenium: It’s Potential Role in Male Infertility. Pak. J. Med. Sci. 25 (2): 332-337.
Telisman, S., Jurasovic, J. and Pangracic, J. (2000): Relationships Between Seminal Fluid Lead Exposure in Men. In; Proceeding of the International Conference on Heavy Metals In the Environment. Edin. UK: CEP. Cons., 14-17.
Umeyama, T. H., Ishikawa, H. and Takeshima, H. (1998): A Comparative Study of Seminal Trace Elements in Fertile and Infertile Men. Fertil. Steril., 46: 494-499.
Omu, A. E., Dashti, H., Mohamed, A. T. and Mattappallil, A. B. (1995): Significance of trace elements in seminal plasma of infertile men. Nutrition 11 (5 Suppl): 502-5.
Open Science Scholarly Journals
Open Science is a peer-reviewed platform, the journals of which cover a wide range of academic disciplines and serve the world's research and scholarly communities. Upon acceptance, Open Science Journals will be immediately and permanently free for everyone to read and download.
Office Address:
228 Park Ave., S#45956, New York, NY 10003
Phone: +(001)(347)535 0661
Copyright © 2013-, Open Science Publishers - All Rights Reserved