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Synthesis of Some New Bis(Mannich Bases) Related to Succinimide and Benzamide and Evaluation of Their Antibacterial and Antifungal Activities
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Volume 4, 2017
Issue 4 (August)
Pages: 26-35   |   Vol. 4, No. 4, August 2017   |   Follow on         
Paper in PDF Downloads: 46   Since Nov. 23, 2017 Views: 1076   Since Nov. 23, 2017
Ebrahim Abdel-Galil, Chemistry Department, Science Faculty, Mansoura University, Mansoura, El-Dakahlia, Egypt.
Norelhoda Salah Abdellatif, Chemistry Department, Science Faculty, Mansoura University, Mansoura, El-Dakahlia, Egypt.
Soha Mostafa Abdelmageed, Chemistry Department, Science Faculty, Mansoura University, Mansoura, El-Dakahlia, Egypt.
Elsayed Mohamed Afsah, Chemistry Department, Science Faculty, Mansoura University, Mansoura, El-Dakahlia, Egypt.
Treatment of Succinimide (1) with the appropriate aldehyde and amine afforded Mannich bases 2a-f, 3 and 4 and the bis(Mannich bases) 5-8. The Mannich bases 2a-fwere used as precursors in synthesis of the new mixed bis(Mannich bases) 9a-c, 10a-c, 11a,b and 12a,b. Mannich reaction of benzamide (13) and the mixed diamide 17 with the appropriate aldehyde and amine gave the Mannich bases 14-16, 18 and 19. In addition, N-amidomethylation of tetrahydrocarbazole (21) and its benzo derivative 23 with the amidic Mannich bases 20a-c afforded compounds22a-c and 24a-c, respectively.
Bis(Mannich Bases), Mixed Mannich Bases, Amidic Mannich Bases
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