Welcome to Open Science
Contact Us
Home Books Journals Submission Open Science Join Us News
Identification and Structural Studies of the Salicylic Acid DL-Phenylalanine Cocrystal
Current Issue
Volume 4, 2017
Issue 6 (December)
Pages: 49-58   |   Vol. 4, No. 6, December 2017   |   Follow on         
Paper in PDF Downloads: 35   Since Jan. 25, 2018 Views: 1054   Since Jan. 25, 2018
Authors
[1]
Mohamed Atiega Elbagerma, Department of Chemistry, Faculty of Science, University of Misurata, Misurata, Libya.
[2]
Howell GM Edwards, Department of Chemical and Forensic Sciences, Faculty of Life Sciences, University of Bradford, Bradford, UK.
[3]
Adel Imhemed Alajtal, Department of Chemistry, Faculty of Science, University of Misurata, Misurata, Libya.
[4]
Ian Ja Scowen, School of Chemistry, College of Science, University of Lincoln, Lincoln, UK.
Abstract
This paper reports the synthesis, experimental study of a novel organic-organic cocrystal energetic material. The molecular and crystal structures of cocrystal are determined by means of x-ray powder diffraction (XRD)/X-ray crystallography, Raman spectroscopy and differential scanning calorimetry. Raman spectroscopy was particularly useful for characterization of the products and was used to determine the nature of the interaction in the cocrystals. Several new vibrational bands were identified in the cocrystal which were not manifest in the raw material and could be used as diagnostic features of cocrystal formation. An understanding of the effects of cocrystal formation on the vibrational mode was obtained by complete assignment of the spectra of the starting material and of cocrystal component. Single crystal X- ray studies confirmed the formation of a cocrystal with a 1:1 stoichiometry between salicylic acid and DL-phenylalanine. The asymmetric unit of the cocrystal contains four molecules: two molecules of salicylic acid and both R- and S- enantiomers of phenylalanine. Each of the phenylalanine molecules is in the zwitterion form.
Keywords
Cocrystals, Raman Spectroscopy, Salicylic Acid, Single-Crystal and X-ray Diffraction
Reference
[1]
Blagden, N.; de Matas, M.; Gavan, P. T.; York, P. AdV. Drug. DeliVery ReV. 2007, 59. p. 617-630.
[2]
Rodriguez-Spong, B.; Price, C. P.; Jayasankar, A.; Matzger, A. J.; Rodrı´guez-Hornedo, N. AdV. Drug DeliVery ReV. 2004, 56. p. 241-274.
[3]
One general example: Weyna, D. R.; Shattock, T.; Vishweshwar, P.; Zaworotko, M. J. Cryst. Growth Des 2009, 9. p. 1106-1123.
[4]
One general example: Frisˇc˘ic´, T.; Jones, W. Cryst. Growth Des 2009, 9. p. 1621-1637.
[5]
Friscic, T.; Childs, S. L.; Rizvi, S. A. A.; Jones, W. CrystEngComm 2009, 11. p. 418-426.
[6]
Blagden, N.; Berry, D. J.; Parkin, A.; Javed, H.; Ibrahim, A.; Gavan, P. T.; De Matos, L. L.; Seaton, C. C. New J. Chem. 2008, 32. p. 1659-1672.
[7]
Sheikh A. Y., Abd Rahim S., Hammond R. B., Roberts K. J., CrystEngComm., 2009. 11. p. 501-509.
[8]
Aakeroy C. B., Salmon D. J., CrystEngComm., 2005. 7. p. 439-448.
[9]
Bettinetti G., Caira M., Callegari A., Merli M., Sorrenti M., Tadini C., J. Pharm. Sci., 2000. 89. p. 478-488.
[10]
M. R. Caira., J. Cryst. Spectrosc., 1992. 22. p. 193-200.
[11]
Caira M. R., Nassimbeni L. R., Wildervanck A. F., J. Chem. Soc. Perkin Trans., 1995. 2. p. 2213-2216.
[12]
Etter M. C., Frankenbach G. M., Chem. Mater., 1989. 1. p. 10-12.
[13]
Etter M. C., Frankenbach G. M., Adsmond A D., Mol. Cryst. Liq. Cryst., 1990. 187. p. 25-39.
[14]
Etter M. C., Reutzel S. M., J. Am. Chem. Soc., 1991. 113. p. 2586-2598.
[15]
Etter M. C., J. Phys. Chem., 1991. 95. p. 4601-4610.
[16]
Nangia A., Desiraju G. R., Acta Crystallogr., 1998. A54. p. 934-944.
[17]
Rodriguez-Spong B., Price C. P., Jayasankar A., Matzger A. J., Rodríguez-Hornedo N., Adv. Drug. Del. Rev., 2004. 56. p. 241-274.
[18]
Desiraju G. R., Acc. Chem. Res., 2002. 35. p. 565-573.
[19]
Rajesh G., Gonnade, Sekai Iwama, Yuko Mori, Hiroki Takahashi, Hirohito Tsue, and Rui Tamura, Cryst. Growth Des., 2011, 11 (2). p 607-615.
[20]
Elbagerma M. A., Edwards H. G. M., Munshi T., Scowen I. J., Anal. Bioanal. Chem., 2010. 397. P 137-146.
[21]
Ravikumar B. R., Rajaram K., Ramakrishnan V., J. Raman Spectrosc., 2006. 37. p. 597-605.
[22]
Rajkumar B. J. M., Ramakrishnan V., Spectrochim. Acta Part A., 2002. 58. p. 1923-1934.
[23]
Ramachandran E., Natarajan N., Cryst. Res. Technol., 2007. 42. p. 617-620.
[24]
Mary M. B., Sasirekha V., Ramakrishnan V., Spectrochim. Acta Part A., 2005. 62. p. 446-452.
Open Science Scholarly Journals
Open Science is a peer-reviewed platform, the journals of which cover a wide range of academic disciplines and serve the world's research and scholarly communities. Upon acceptance, Open Science Journals will be immediately and permanently free for everyone to read and download.
CONTACT US
Office Address:
228 Park Ave., S#45956, New York, NY 10003
Phone: +(001)(347)535 0661
E-mail:
LET'S GET IN TOUCH
Name
E-mail
Subject
Message
SEND MASSAGE
Copyright © 2013-, Open Science Publishers - All Rights Reserved