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Efficient Synthesis of Some Benzochromenone Analogues as Potential Novel Antioxidant and Antimicrobial Agents
Current Issue
Volume 4, 2017
Issue 2 (April)
Pages: 9-17   |   Vol. 4, No. 2, April 2017   |   Follow on         
Paper in PDF Downloads: 35   Since Sep. 27, 2017 Views: 1166   Since Sep. 27, 2017
Hala Ahmed Abd El-Aty, Department of Chemistry, Faculty of Science, Mansoura University, Mansoura, Egypt.
El-Sayed Ibrahim El-Desoky, Department of Chemistry, Faculty of Science, Mansoura University, Mansoura, Egypt.
Abdel-Rahman Hassan Abdel-Rahman, Department of Chemistry, Faculty of Science, Mansoura University, Mansoura, Egypt.
New benzo[f]chromen-1-one derivatives were prepared by a sequence of reactions starting from appropriate 1-(2,3-dihydroxynaphthalen-1-yl)ethanone. The prepared target compounds were confirmedupon correct elemental analysis and spectroscopic data. Compounds were evaluated as antioxidant agents using DPPH assay and ascorbic acid was used as a reference drug. Compounds 3 (inhibitive concentration (IC50) = 0.0013 mg/mL), 7 (IC50= 0.013 mg/mL) and 10 (IC50= 0.0166 mg/mL) have the best activities higher than ascorbic acid, in which compound 3 is the best antioxidant agent. The prepared compounds were evaluated as antibacterial agents against Gram (+)- and Gram (-)-bacterial strainsusing streptomycin as a reference drug. In general, most the tested compounds are considered as potent antioxidant and antibacterial agents compared to standard substances. Compound 3 exhibited the highest antibacterial activity compared to streptomycin. We hope in future work that compound 3 could be used in drug design for developingnew antioxidant agent with good property.
2,3-Dihydroxynaphthalene, Benzochromenones, Organic Synthesis, Antioxidant and Antimicrobial Activities
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