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Determination of Plasmodium Specific Immunoglobulin G and M in Patients with Malaria in Ikorodu, Lagos, Nigeria
Current Issue
Volume 6, 2018
Issue 1 (February)
Pages: 1-7   |   Vol. 6, No. 1, February 2018   |   Follow on         
Paper in PDF Downloads: 41   Since Jan. 25, 2018 Views: 431   Since Jan. 25, 2018
Authors
[1]
Elekhebor E. John, Department of Medical Laboratory Science, Faculty of Basic Medical Sciences, University of Benin, Benin City, Nigeria.
[2]
Wellington A. Oyibo, Department of Medical Microbiology and Parasitology, College of Medicine University of Lagos, Lagos, Nigeria.
[3]
Dic-Ijiewere O. Ebenezer, Department of Chemical Pathology, Faculty of Clinical Sciences, College of Medical Sciences, Ambrose Alli University, Ekpoma, Nigeria.
[4]
Airhomwanbor O. Kingsley, Department of Medical Laboratory Science, Faculty of Basic Medical Sciences, Ambrose Alli University, Ekpoma, Nigeria.
[5]
Idehen I. Charles, Department of Medical Laboratory Science, Faculty of Basic Medical Sciences, Ambrose Alli University, Ekpoma, Nigeria.
Abstract
This study was conducted to determine the presence of Plasmodium specific IgG/IgM, its relationship with clinical symptoms, parasite density, age and sex in four primary health care facilities in Ikorodu Lagos, Nigeria. A total number of 1218 patients 450(36.9%) male and 768(63.1%) female were recruited for the study. Microscopy method was used to screen the patients of which 235 were positive for malaria parasite. A total of 167 sera was pooled out from the positive samples and tested for Plasmodium specific IgG/IgM using enzyme linked immunosorbent assay (ELISA). 135(83.9%) were positive for Plasmodium specific IgG/IgM and presenting with fever, while 26(16.1%) were negative with fever. The parasite density was 30671.71 ± 31809.3 with majority of participants that had moderate parasitaemia and presented with fever, having higher positivity for Plasmodium specific IgG/IgM 41(89.15%) while 5(10.9%) with fever and moderate parasitaemia were negative for Plasmodium specific IgG/IgM. There was no significant correlation between IgG/IgM and clinical signs/symptom, parasite density, age and sex (P > 0.05). These findings demonstrated that individuals living in this community mount a strong antibody response against P. falciparum parasites and these antibodies persist as a result of infection and re-infection irrespective of clinical presentation, age and sex differences.
Keywords
Malaria, Plasmodium, Immunoglobulin, Primary Health
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