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Liquid Chromatographic and Potentiometric Methods for the Determination of Oxomemazine in Pharmaceutical Preparations
Current Issue
Volume 5, 2017
Issue 3 (June)
Pages: 12-18   |   Vol. 5, No. 3, June 2017   |   Follow on         
Paper in PDF Downloads: 30   Since Aug. 14, 2017 Views: 594   Since Aug. 14, 2017
Authors
[1]
Mohamed Alaa Fathy Elmosallamy, Department of Chemistry, Faculty of Science, Zagazig University, Zagazig, Egypt.
[2]
Amr Lotfy Saber, Department of Chemistry, Faculty of Science, Zagazig University, Zagazig, Egypt; Department of Chemistry, Faculty of Science, Umm Al Qura University, Makkah, Saudi Arabia.
[3]
Alaa Said Amin, Department of Chemistry, Faculty of Science, Benha University, Benha, Egypt.
[4]
Hamada Mohammed Ahmed Killa, Department of Chemistry, Faculty of Science, Zagazig University, Zagazig, Egypt.
Abstract
Simple and selective two different techniques are developed for the determination of oxomemazine in pharmaceutical preparations. A rapid (less than 6 min) and accurate high performance liquid chromatography(HPLC) method has been developed where chromatographic analysis is performed on Nova-Pak® C18 column (3.9 mm × 150 mm, 5 µm) with an ammonium formate buffer adjusted with formic acid to pH 3.0 and acetonitrile (75: 25, v/v) as a mobile phase, and detection at 235 nm. Good linearity (0.99, r 2), accuracy (≥ 99.20%), and precision (≤ 0.6 RSD) were obtained. Potentiometric measurements are based on tetrakis (p -chlorophenyl) borate-oxomemazine ion-pair complex as an electroactive species incorporating in a plasticized poly vinyl chloride (PVC) membrane with o-nitrophenyl octyl ether (o -NPOE) or dioctyl phthalate (DOP). The sensor exhibits fast and stable Nernstian response for oxomemazine over the concentration range of 1.0 × 10-5 – 1.0 × 10-2 mol L-1 and pH range of 3.5 - 6.0. The sensor shows reasonable selectivity towards oxomemazine hydrochloride over many cations. No significant interferences are caused by drug excipients and diluents. Results with an average recovery of 100.6% and a mean standard deviation of 0.77% of the nominal were obtained.
Keywords
HPLC, Potentiometry, Oxomemazine Hydrochloride, Pharmaceutical Preparations
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