Acute Toxicity and Histological Findings of Aqueous Stem Extract of Pennisetum purpureum on Alloxan–Induced Diabetic Wistar-Albino Rats
Acute toxicity and histological findings of aqueous stem extract of Pennisetum purpureum on alloxan–induced diabetic wistar-albino rats was studied. Acute toxicity of the plant were orally administered to four groups (100mg/kg, 1000mg/kg, 5000mg/kg and 10000mg/kg) of rats for a day and LD50 observed at 7071mg/kg, making the plant relatively safe for consumption. Histopathological study of the liver and pancreas on alloxan induced diabetic wistar albino rats was carried out on 24 albino rats, which were divided into six groups of four rats each designated as C, D, D200mg/kg, D400mg/kg, D600mg/kg and Dmet®. Diabetes was induced in all the groups, except group C (positive control). Group D (negative control) was not treated while the other groups were treated with aqueous stem extracts of Pennisetum purpureum and a reference drug (metformin® 1.4mg/kg), which were administered orally to the animals once daily for 21 days at varying concentrations of 200mg/kg, 400mg/kg and 600 mg/kg body weights. Histological studies showed that the extract (400mg/kg) improved the liver cells and the pancreatic cells. These findings suggest that the extract at 400mg/kg can be used therapeutically for the management of diabetes mellitus.
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