Twenty (20) albino rats of both sexes were divided into five groups of four animals each and tested for body weight as well as haematological parameters such as: PCV, WBC, HB, RBC, MCV, MCHC and MCH methanol leaf extract of F. exasperata. The test groups II, III, IV and V were fed with extract doses of 100, 200, 300 and 400mg/kg body weight of mice respectively by oral means for two weeks. Initial weights of the rats and weights after feeding were taken, and then the animals were sacrificed after two weeks. Blood samples collected from the sacrificed animals were analysed for haematological parameters. Results showed that weights of the animals increase as the doses increase in all the groups except for the control group (I) where the animals were given ordinary water. General decreases in haematological parameters PCV, HB, WBC, MCHC and MCV were witnessed whilst the RBC showed significant increases (P≤0.05) compared with the control value 5.05 ± 0.31x106 mm3. The study indicated that long term use of the leaves of F. exasperata as an oral medication in traditional medicine was not safe at the doses investigated in this study, as the weight increase in the animals may be due to hypertrophy (swollen organs) except in the control group without the extract.
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