A Novel Action of Silver Nanoparticles for Skin Repair
The Silver nanoparticles have been widely used as new potent antimicrobial agents in cosmetic and hygienic products, as well as in new medical devices. Silver compounds have also been used for centuries for healing purposes because of the broad spectrum antibiotic, and have been proven to be effective in both, retarding and preventing bacterial infections and healing wounds. In this study the evaluation of healing properties of Silver nanoparticles has done by using hydrophilic ointment containing nanosilver. This ointment was prepared and used for anti-inflammatory and wound healing study. In the study of silver nanoparticls effect on anti-inflammatory study showed reduces edema with 91% (inhibition percentages) as compared to standard which showed 81% (inhibition percentages). In further study of Silver nanoparticle had shown significant therapeutic activity in excision wound study. In this study the mean percentage closure of wound for AgNP used in 1% of concentration had shown better result with 95.28% in comparison with standard which was around 93.71%. This was further confirmed by the collagen and epithelization studies. There was significant difference between the entire group and the 1% AgNP ointment was found to be highly effective. As the collagen synthesis is the first step due to the formation of precursor polypepetide such as lysine and proline residues. The remolding of scar tissue occurs due to the fast inter molecular and intra molecular cross linking of collagen. Collagen not only confers strength and integrity to the tissue matrix but also plays an important role in hemostasis and epithelialization at alater phase of wound healing. With this study we can state that the use of Silver nanoparticles in cosmetic formulation can help in reducing wrinkles and increase the firmness of the skin as well as it can be used in anti-acne preparation efficiently.
Silver Nanoparticle, Wound Healing, Cosmetic, Acne, Antiaging, Skin Rejuvenation, Collagen Booster
Swati Gajbhiye, Satish Sakharwade, “Silver Nanoparticles in Cosmetics”, Journal of Cosmetics, Dermatological Sciences and Applications, 2016, 6, 48-53.
Wong KKY, Liu XL, “Silver nanoparticles-the real ‘silver bullet’ in clinical medicine?” Med Chem Communications, 2010, Volume 1, Issue 2, Page no: 125-131.
Wim H De Jong and Paul J A Borm, “Drug delivery and nanoparticles: Application sandhazards”, International Journal of Nanomedicine. 2008 Jun; Volume 3 Issue 2, Page no: 133–149.
Geewoo Nam, Sabarinathan Rangasamy, Baskaran Purushothamanand Joon Myong Song, “The Application of Bactericidal Silver Nanoparticles in Wound Treatment”, Journal of Nanomater Nanotechnol, 2015, Page no: 1-14.
Irena Pastar, Olivera Stojadinovic, Natalie C. Yin, Horacio Ramirez, Aron G. Nusbaum, Andrew Sawaya, Shailee B. Patel, Laiqua Khalid, Rivkah R. Isser off, and Marjana Tomic-Canic, “Epithelialization in Wound Healing: A Comprehensive Review”, Journal of Advance in Wound Care (NewRochelle). 2014 Jul 1; Volume 3 Issue 7, Page no: 445–464.
Chiara Rigo, Letizia Ferroni, Ilaria Tocco, Marco Roman, Ivan Munivrana, Chiara Gardin, Warren R. L. Cairns, Vincenzo Vindigni, Bruno Azzena, Carlo Barbante and Barbara Zavan, “Active Silver Nanoparticles for Wound Healing”, International Journal of Molecular Science. 2013, 14, Page no: 4817-4840; doi: 10.3390/ijms14034817.
Zakieh Boroum and, Nahid Golmakani, Safieh Boroumand, “Clinical trials on silver nanoparticles for wound healing”, Nano med Journal. 2018; 5 (4), Page no: 186-191. DOI: 10.22038/nmj.2018.05.00001.
Amani D. Politano, Kristin T. Campbell, Laura H. Rosenberger, and Robert G. Sawyer, “Use of Silver in the Prevention and Treatment of Infections: Silver Review”, Journal of Surgical Infection, 2013 Feb; Volume 14, Issue 1, page no: 8–20.
Rajan Michael Evanjaline, Veerabahu Ramasamy Mohan, “Evaluation of Antiinflammatory Activity of Whole Plant of Carallumaumbellata Haw. (Apocynaceae) In Albino Rats”, Haya: The Saudi Journal of Life Sciences (SJLS), Published: 30.01.2018, Page no: 32-35, DOI: 10.21276/haya.2018.3.1.7.
John D. Stroncekand W. Monty Reichert., “In dwelling Neural Implants: Strategies for Contending with the In Vivo Environment.”, Chapter 1 Overview of Wound Healing in Different Tissue Types, Editor: William M Reichert, Boca Raton (FL): C R C Press/Taylor & Francis; 2008.
T Velnar, T Bailey And V Smrkolj, “The Wound Healing Process: an Overview of the Cellular and Molecular Mechanisms”, The Journal of International Medical Research 2009; 37: 1528-1542.
Sarika Amdekar, Purabi Roy, Vinod Singh, Avnish Kumar, Rambir Singh, and Poonam Sharma, “Anti-Inflammatory Activity of Lacto bacillus on Carrageenan-Induced Paw Edemain Male Wistar Rats”, International Journal of Inflammation, volume 2012, page no 1-6, Article ID 752015, doi: 10.1155/2012/752015.
Tanghetti, Emil A. “The role of inflammation in the pathology of acne.” The Journal of clinical and aesthetic dermatology, vol. 6, 9 (2013), page no: 27-35.
Ibrahim, Nurul' Izzahetal. “Wound Healing Properties of Selected Natural Products.” International journal of environmental research and public health vol. 15, 112360. 25Oct. 2018, doi: 10.3390/ijerph15112360.
Chun Qing, “The molecular biology in wound healing & non-healing wound”, Chinese Journal of Traumatology 20 (2017), page no 189-193.
Hemant Kumar Nagar, Amit Kumar Srivastava, Rajnish Srivastava, Madan Lal Kurmi, Harinarayan Singh Chandel, and Mahendra Singh Ranawat, “Pharmacological Investigation of the Wound Healing Activity of Cestrumnocturnum (L.) Ointment in Wistar Albino Rats”, Hindawi Publishing Corporation, Journal of Pharmaceutics, Volume 2016, Article ID 9249040, Pageno1-8, http://dx.doi.org/10.1155/2016/9249040.
Grubbs H, Manna B. Wound Physiology. [Updated2018Nov5]. In: Stat Pearls [Internet]. Treasure Island (FL): Stat Pearls Publishing; 2019Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK518964/.
Hema Sharma Datta, Shankar Kumar Mitra, and Bhushan Patwardhan, “Wound Healing Activity of Topical Application Forms Based on Ayurveda,” Evidence-Based Complementary and Alternative Medicine, vol. 2011, Article ID 134378, 10 pages, 2011. https://doi.org/10.1093/ecam/nep015.
Lodish H, Berk A, Zipursky SL, et al. Molecular Cell Biology. 4th edition. New York: W. H. Freeman; 2000. Section 22. 3, Collagen: The Fibrous Proteins of the Matrix. Available from: https://www.ncbi.nlm.nih.gov/books/NBK21582/.
John Kraft, M D and Anatoli Freiman, MD, “Management of acne”, journal of CMAJ. 2011 Apr19; 183 (7): E430–E435. doi: 10.1503/cmaj.090374.