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Antioxidant Status of Nigerians with Diabetic Disorders
Current Issue
Volume 1, 2014
Issue 2 (March)
Pages: 13-15   |   Vol. 1, No. 2, March 2014   |   Follow on         
Paper in PDF Downloads: 20   Since Aug. 28, 2015 Views: 1736   Since Aug. 28, 2015
Genesis YR, Department of Chemical Pathology, University of Maiduguri, Nigeria.
Ezimah ACU, Department of Physiology, Federal University Ndufu-Alike Abakaliki, Nigeria.
Ugwushi C, Department of Physiology, Federal University Ndufu-Alike Abakaliki, Nigeria.
Odo P, Department of Physiology, Federal University Ndufu-Alike Abakaliki, Nigeria.
Ajugwo AO, Department of Haematology and Blood Transfusion, Madonna University Elele, Nigeria.
During the past few years, identification of many molecules that participate in cellular processes has contributed to the information on pathogenesis in many non-communicable diseases. The present study was undertaken to evaluate total antioxidant status (TAS) as a factor in the pathogenesis of diabetes mellitus. The study included 88 diabetic patients and 30 apparently healthy non-diabetic controls. On the basis of biochemical attributes, the different types of diabetics in the study groups were gestational diabetes mellitus GDM (22%), insulin dependent diabetes mellitus IDDM (23%), and non-insulin dependent diabetes mellitus NIDDM (55%). Blood glucose levels and plasma total antioxidant status were determined using standard methods. Plasma total antioxidant status levels were significantly lower in the diabetic groups than in controls (p<0.05). This finding was independent of the type of diabetes. On comparative basis, the lowest value of TAS was predominantly found amongst the IDDM. In this study, plasma TAS levels are markedly reduced in patients with all types of diabetes and hence an indication of the involvement of reactive oxygen species in the pathogenesis of diabetes and can be used as a prognostic marker in diabetic patients.
Diabetic Disorders, Antioxidant Status, Pathogenesis, Oxidative Stress
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